Longevity

Epigenetic clocks claim to measure 'biological age' from DNA methylation patterns. The research is real; the consumer products have validation issues and the actionability is much smaller than the marketing implies.

4 min read · Last reviewed 2026-05-19

The Blue Zones — Sardinia, Okinawa, Loma Linda, Nicoya, Ikaria — have become a fixture of popular longevity discourse. Recent statistical work has challenged some of the underlying data. What's robust and what isn't.

4 min read · Last reviewed 2026-05-19

Caloric restriction extends lifespan in many species. The CALERIE-2 trial — the largest human RCT — produced cleaner data on what CR does in non-obese adults. The benefits are real; the longevity claims still extrapolate.

4 min read · Last reviewed 2026-05-19

Hormesis — beneficial adaptation to low-dose stress — is the implicit theory behind exercise, cold exposure, fasting, and sauna. A look at what the concept actually claims, where it's supported, and where it gets overextended.

3 min read · Last reviewed 2026-05-18

PREDIMED. The most-cited dietary RCT in longevity research. What the Mediterranean diet pattern actually is, what the trials show, and why it has stronger evidence than any other dietary intervention.

5 min read · Last reviewed 2026-05-19

Metformin is a first-line diabetes medicine that has been proposed as a healthspan-extending intervention in non-diabetics. The hypothesis is plausible; the human evidence is much more limited than the headlines suggest.

3 min read · Last reviewed 2026-05-18

Nicotinamide riboside and nicotinamide mononucleotide are widely marketed as longevity supplements. The cell biology is real; the human clinical evidence is much thinner than the marketing suggests.

3 min read · Last reviewed 2026-05-18

Peter Attia's framework from 'Outlive' organises longevity around exercise, nutrition, sleep, and emotional health. A look at what's evidence-based, what's extrapolation, and what the framing adds.

4 min read · Last reviewed 2026-05-19

Rapamycin is the most-discussed mTOR inhibitor in the longevity space. It's a prescription-only medicine in the UK with a serious side-effect profile. Here's what the published research says — without dosing guidance.

3 min read · Last reviewed 2026-05-18

Senolytics target senescent 'zombie' cells implicated in ageing. The mouse data is striking; the human trials are small, early, and the marketing dramatically outpaces the evidence.

3 min read · Last reviewed 2026-05-19

Spermidine is a naturally occurring polyamine sold as a longevity supplement on autophagy-related claims. A look at the food sources, the human evidence, and what gets oversold.

3 min read · Last reviewed 2026-05-18